Autism spectrum disorder and early-life stress converge on systemic hyperexcitability and stress epigenetics. NR3C1, FKBP5, and GAD1, the GABA synthesis gene, are epigenetically set toward a heightened excitatory state marked by increased arousal, sensitivity, and excitation–inhibition imbalance.

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Autism spectrum disorder and early-life stress converge on systemic hyperexcitability and stress epigenetics. NR3C1, FKBP5, and GAD1, the GABA synthesis gene, are epigenetically set toward a heightened excitatory state marked by increased arousal, sensitivity, and excitation–inhibition imbalance.

Autism spectrum disorder and early-life stress converge on systemic hyperexcitability and stress epigenetics. NR3C1, FKBP5, and GAD1, the GABA synthesis gene, are epigenetically set toward a heightened excitatory state marked by increased arousal, sensitivity, and excitation–inhibition imbalance.

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